Oxidation of l -Methionine by Bisperoxo(1,10-phenanthroline)oxovanadate(V): A Mechanistic Study
作者： Sanchita Chakrabarty , Rupendranath Banerjee
DOI: 10.1002/KIN.20990
关键词: Stoichiometry 、 Methionine 、 Electron paramagnetic resonance 、 Methionine sulfoxide 、 Inorganic chemistry 、 Reaction rate constant 、 Medicinal chemistry 、 Phosphate buffered saline 、 Chemistry 、 Phenanthroline 、 Physical and Theoretical Chemistry 、 Organic chemistry 、 Biochemistry
摘要: In phosphate buffer media (pH 5.8–8.0), bisperoxo(1,10-phenanthroline)oxovanadate(V) (1) oxidizes l-methionine to methionine sulfoxide. The stoichiometry of the reaction is 1:1. occurs in two subsequent first-order steps. first step, one peroxo ligands 1 gets substituted by l-methionine. observed rate constants for both steps increase linearly with increasing [H+] as well [l-methionine]. EPR spectra prove that involves a cysteinyl radical-type intermediate and VV reduced VIV species.
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