Biology of tumor necrosis factor-alpha- implications for psoriasis.

摘要: Numerous recent investigations have pointed to a key role of the proinflammatory, pleiotropic cytokine tumor necrosis factor-alpha (TNF-alpha) in host defense and inflammatory processes. TNF overexpression has been found lesional skin circulation psoriatic patients, it was suggested that TNF-alpha is crucial this other immune diseases. Several approaches inhibit activity developed. These include three different neutralizing antibodies as well soluble receptors with characteristic properties designed bind 17-KDa trimeric 26-KDa membrane-bound form TNF-alpha. Clinical trials demonstrated significant antipsoriatic effects, likely blocking will become an important therapeutic option. The data available from these contribute further understanding disease by demonstrating major An in-depth regulation gene expression, protein production, receptor signaling pathways may lead further, potentially novel strategies active small molecules, suitable for oral application future. Here we review current knowledge biology, activity, their clinical immunological effects psoriasis. In addition, host-defense chronic TNF-blocking are discussed.