Immunofluorescence, Necrobiosis Lipoidica, and Blood Vessels
作者： Mark V. Dahl
DOI: 10.1001/ARCHDERM.1988.01670090073017
关键词: Necrobiosis lipoidica 、 Inflammation 、 Biopsy 、 Vasculitis 、 Immunofluorescence 、 Pathology 、 Immunopathology 、 Medicine 、 Necrobiosis 、 Direct fluorescent antibody
摘要: In this issue of theArchives, Quimby et al 1 discuss the cutaneous immunopathology necrobiosis lipoidica diabeticorum (NLD). They studied biopsy specimens obtained from 12 patients with NLD by direct immunofluorescence and found following fluorescing immunoreactants in involved skin 11 patients: IgM (six patients), C3 (nine IgG (one patient), IgA (two patients). Even uninvolved skin, vessels contained deposits. was deposited three patients, four, one. Ullman I 2,3 first examined blood for presence immune deposits a decade ago because histologic features suggested vasculopathy. Nonetheless, we were bit surprised to find them. Immune complexes are frequently associated vasculitis. Yet, indolent plaques do not reek clinical signs vasculitis—purpura, edema, necrosis. Furthermore, inflammation around
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