Fetal loss in Down syndrome pregnancies.

摘要: It is recognized that pregnancies with Down syndrome are liable to end in spontaneous fetal loss. important determine the magnitude of this effect so it can be taken into account when assessing results antenatal screening programmes for syndrome. Failure do will tend overestimate detection rate intervention studies which used identify women a diagnostic test and offer termination pregnancy if indicated. We present new data on loss from National Syndrome Cytogenetic Register (1989–1996). We compare our published other subject obtain summary estimate. exclude one study meta analysis due incorrect methodology resulting an Based combined (i) between time chorionic villus sampling term estimated 43 per cent (95 CI: 31–54 cent) ended miscarriage or still birth, (ii) amniocentesis 23 19–28 (iii) 12 2–23 births were stillborn resulted neonatal death. Copyright © 1999 John Wiley & Sons, Ltd.