Modulation of pulmonary DC function by vaccine-encoded GM-CSF enhances protective immunity against Mycobacterium tuberculosis infection.
作者： Jonathan K. Nambiar , Anthony A. Ryan , Carlyn U. Kong , Warwick J. Britton , James A. Triccas
关键词: Cytokine 、 Vaccination 、 Lung 、 Virology 、 BCG vaccine 、 Mycobacterium tuberculosis 、 Immune system 、 Biology 、 Mycobacterium bovis 、 Tuberculosis 、 Immunology
摘要: The rational design of new vaccines engineered to target key components the host immune response is crucial aid control important infectious diseases such as tuberculosis. In this report, we determined whether modifying function pulmonary APC could improve protection against infection with Mycobacterium Targeted delivery lung cytokine GM-CSF, expressed by bovis BCG vaccine strain, increased DC numbers and secretion immunoregulatory IL-12, compared parental immunization. This impact on number BCG:GM-CSF resulted in accelerated priming antigen-specific CD4+ T cells mediastinal lymph nodes migration activated into lung. i.n. administration significantly M. tuberculosis mice vaccinated alone. exhibited an improved safety profile, immunodeficient RAG1-/- survived longer than BCG-vaccinated mice. These data demonstrate that manipulating BCG-based GM-CSF can assist development protective mucosal immunity bacterial infection.
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