The effect of 5-lipoxygenase-activating protein (FLAP) on substrate utilization by 5-lipoxygenase.
作者： P. J. Vickers , C. Deluca , E. Wong , M. Abramovitz
DOI: 10.1007/978-1-4615-5325-0_21
关键词: Transfection 、 Arachidonic acid 、 Substrate (chemistry) 、 Enzyme 、 5-lipoxygenase-activating protein 、 Biochemistry 、 Chemistry 、 Integral membrane protein 、 Arc (protein) 、 Arachidonate 5-lipoxygenase
摘要: Transfection studies in human osteosarcoma cells have demonstrated that the enzyme 5-lipoxygenase (5-LO) and integral membrane protein activating (FLAP) are both required for cellular synthesis of leukotrienes (LTs) (1). Consequently compounds which directly inhibit 5-LO (2) or specifically interact with FLAP (3,4) arc potent inhibitors LT currently being asseed treatment diseases LTs implicated.
springer.com
sci-hub.st 参考文章(15)
C A Rouzer, S Kargman, Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187. Journal of Biological Chemistry. ,vol. 263, pp. 10980- 10988 ,(1988) , 10.1016/S0021-9258(18)38066-9
C A Rouzer, A W Ford-Hutchinson, H E Morton, J W Gillard, MK886, a potent and specific leukotriene biosynthesis inhibitor blocks and reverses the membrane association of 5-lipoxygenase in ionophore-challenged leukocytes. Journal of Biological Chemistry. ,vol. 265, pp. 1436- 1442 ,(1990) , 10.1016/S0021-9258(19)40034-3
F. Weitzel, A. Wendel, Selenoenzymes regulate the activity of leukocyte 5-lipoxygenase via the peroxide tone. Journal of Biological Chemistry. ,vol. 268, pp. 6288- 6292 ,(1993) , 10.1016/S0021-9258(18)53251-8
E Hill, J Maclouf, R.C. Murphy, P.M. Henson, Reversible membrane association of neutrophil 5-lipoxygenase is accompanied by retention of activity and a change in substrate specificity. Journal of Biological Chemistry. ,vol. 267, pp. 22048- 22053 ,(1992) , 10.1016/S0021-9258(18)41633-X
D Denis, J P Falgueyret, D Riendeau, M Abramovitz, Characterization of the activity of purified recombinant human 5-lipoxygenase in the absence and presence of leukocyte factors. Journal of Biological Chemistry. ,vol. 266, pp. 5072- 5079 ,(1991) , 10.1016/S0021-9258(19)67757-4
S. Kargman, P. Prasit, J.F. Evans, Translocation of HL-60 cell 5-lipoxygenase. Inhibition of A23187- or N-formyl-methionyl-leucyl-phenylalanine-induced translocation by indole and quinoline leukotriene synthesis inhibitors. Journal of Biological Chemistry. ,vol. 266, pp. 23745- 23752 ,(1991) , 10.1016/S0021-9258(18)54346-5
C. Brideau, C. Chan, S. Charleson, D. Denis, J. F. Evans, A. W. Ford-Hutchinson, R. Fortin, J. W. Gillard, J. Guay, D. Guévremont, J. H. Hutchinson, T. R. Jones, S. Leger, J. A. Mancini, C. S. McFarlane, C. Pickett, H. Piechuta, P. Prasit, D. Riendeau, C. A. Rouzer, P. Tagari, P. J. Vickers, R. N. Young, W. M. Abraham, Pharmacology of MK-0591 (3-[1-(4-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)-indol-2-yl]-2,2-dimethyl propanoic acid), a potent, orally active leukotriene biosynthesis inhibitor Canadian Journal of Physiology and Pharmacology. ,vol. 70, pp. 799- 807 ,(1992) , 10.1139/Y92-107
Angela Wong, Michael N. Cook, Shing Mei Hwang, Henry M. Sarau, James J. Foley, Stanley T. Crooke, Stimulation of leukotriene production and membrane translocation of 5-lipoxygenase by cross-linking of the IgE receptors in RBL-2H3 cells. Biochemistry. ,vol. 31, pp. 4046- 4053 ,(1992) , 10.1021/BI00131A021
B Samuelsson, Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation Science. ,vol. 220, pp. 568- 575 ,(1983) , 10.1126/SCIENCE.6301011
C. A. Rouzer, T. Matsumoto, B. Samuelsson, Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 857- 861 ,(1986) , 10.1073/PNAS.83.4.857