A Model-Based Approach to Optimizing Ultradian Forced Desynchrony Protocols for Human Circadian Research:

摘要: The human circadian system regulates internal 24-h rhythmicity and plays an important role in many aspects of health behavior. To investigate properties the pacemaker such as intrinsic period light sensitivity, experimental researchers have developed forced desynchrony (FD) protocols which manipulations light-dark (LD) cycle are used to desynchronize rhythm from rest-activity cycle. FD typically been based on exposure long LD cycles, but recently, ultradian with short cycles proposed a new methodology for assessing period. However, effects protocol design, including intensity or study duration, estimates not, our knowledge, systematically studied. address this gap, we applied light-sensitive, dynamic mathematical model simulate analyze design We found that optimal were obtained using low intensities, at least 10 d cycling, 7-h duration facilitated uniform across all phases. Our results establish theoretical framework can be provide insights into data under existing optimize future experiments.