Clofibrate, Serum Enzymes, and Muscle Pain

摘要: Serum creatine kinas (C.K.), aspartate amino-transferase (G.O.T.), and alkaline phosphatase (A.P.) activities were measured in 211 men with serum cholesterol concentrations the upper one-third of normal distribution. Of these, 110 receiving clofibrate 101 given identical capsules containing olive oil. These investigations also carried out on 85 healthy low levels not clofibrate. No differences observed C.K. G.O.T. between any these groups; A.P. was significantly lower clofibrate-treated group. significant alterations occurred during serial observations made 15 patients ischaemic heart disease over a period five months. instance myalgia or muscle stiffness recorded 452 who had received for one year. It is concluded that raised occurrence are uncommon accompaniments treatment.