Hematoporphyrin Derivative Rescue from Toxicity Caused by Chemotherapy or Radiation in a Murine Leukemia Model (L1210)

摘要: Hematoporphyrin [1,3,5,8-tetramethyl-2,4-bis(hydroxyethyl)-porphin-6,7-dipropio nic acid dihydrochloride derivative] (HPD) is a compound that was studied in number of laboratories because its cytocidal activity after activation by light. Modification immune function seen during the photochemotherapeutic studies prompted attempts to determine effect HPD on and hemopoietic systems. Splenic hyperplasia as well marrow hypercellularity were noted mice treated with HPD. In vitro phytohemagglutinin or lipopolysaccharide stimulation spleen lymphocytes caused normal scant increases blast transformation compared index for from untreated animals. treatment did not significantly alter production antibody sheep red blood cells, evaluated hemagglutination hemolytic assay. contrast, promote an increased colonies lethally irradiated transfused syngeneic bone marrow. The capacity increase cells has been exploited accelerate recovery peripheral leukopenia induced animals previous drug radiation treatment. time full return severe antimetabolite (5-fluorouracil) alkylating agent (cyclophosphamide X-rays shorter than controls. Furthermore, improved survival demonstrated Finally, L1210 leukemic affect antitumor cyclophosphamide. If properties described here be confirmed, might contribute leukopenic cancer patients.