Stem Cell-Based Approaches to Spinal Cord Injury
作者： Alexa L. Reeves , Hans Keirstead
DOI: 10.1002/3527600906.MCB.201200013
关键词: Adult stem cell 、 Progenitor cell 、 Stem cell 、 Neuroscience 、 Cell potency 、 Endothelial stem cell 、 Embryoid body 、 Neural stem cell 、 Embryonic stem cell 、 Biology
摘要: Stem cells have great potential for the treatment of spinal cord injury (SCI). Different types stem cell include somatic and embryonic, both which unique advantages disadvantages. Here, profile motor neuron progenitor oligodendrocyte derived from human embryonic is discussed, several significant animal model experiments using are reviewed. Clinical trials currently underway or planned these SCI therapy will also be discussed. Finally, it proposed that may most useful clinically applicable therapeutic use. Keywords: Bone marrow stromal cell; Embryonic cell; Human cell-derived cell; Induced pluripotent cell; Neural cell; Spinal
sci-hub.se 参考文章(91)
Mercedes Zurita, Javier Vaquero, Bone marrow stromal cells for spinal cord repair: a challenge for contemporary neurobiology. Histology and Histopathology. ,vol. 24, pp. 107- 116 ,(2009) , 10.14670/HH-24.107
Jingyi Shi, Adrian Marinovich, Ben A. Barres, Purification and Characterization of Adult Oligodendrocyte Precursor Cells from the Rat Optic Nerve The Journal of Neuroscience. ,vol. 18, pp. 4627- 4636 ,(1998) , 10.1523/JNEUROSCI.18-12-04627.1998
Frédéric Bretzner, Frédéric Gilbert, Françoise Baylis, Robert M. Brownstone, Target populations for first-in-human embryonic stem cell research in spinal cord injury. Cell Stem Cell. ,vol. 8, pp. 468- 475 ,(2011) , 10.1016/J.STEM.2011.04.012
R. K. Margolis, R. U. Margolis, Nervous tissue proteoglycans. Cellular and Molecular Life Sciences. ,vol. 49, pp. 429- 446 ,(1993) , 10.1007/BF01923587
Yi Wei Zhang, Jerrod Denham, R. Scott Thies, Oligodendrocyte progenitor cells derived from human embryonic stem cells express neurotrophic factors. Stem Cells and Development. ,vol. 15, pp. 943- 952 ,(2006) , 10.1089/SCD.2006.15.943
Qin Chen, Yan Long, Xiaoqing Yuan, LingLong Zou, Jiao Sun, Shengdi Chen, J. Regino Perez-Polo, Keyi Yang, Protective effects of bone marrow stromal cell transplantation in injured rodent brain: Synthesis of neurotrophic factors Journal of Neuroscience Research. ,vol. 80, pp. 611- 619 ,(2005) , 10.1002/JNR.20494
Jerònia Lladó, Christine Haenggeli, Nicholas J. Maragakis, Evan Y. Snyder, Jeffrey D. Rothstein, Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors Molecular and Cellular Neuroscience. ,vol. 27, pp. 322- 331 ,(2004) , 10.1016/J.MCN.2004.07.010
Melissa K. Carpenter, Margaret S. Inokuma, Jerrod Denham, Tahmina Mujtaba, Choy-Pik Chiu, Mahendra S. Rao, Enrichment of neurons and neural precursors from human embryonic stem cells. Experimental Neurology. ,vol. 172, pp. 383- 397 ,(2001) , 10.1006/EXNR.2001.7832
Chang Zhou, Chen Zhang, Song Chi, Yiongfeng Xu, Jijun Teng, Haiping Wang, Yuqiang Song, Renliang Zhao, Effects of human marrow stromal cells on activation of microglial cells and production of inflammatory factors induced by lipopolysaccharide Brain Research. ,vol. 1269, pp. 23- 30 ,(2009) , 10.1016/J.BRAINRES.2009.02.049
Daša Čížková, Ján Rosocha, Ivo Vanický, Stanislava Jergová, Milan Čížek, Transplants of Human Mesenchymal Stem Cells Improve Functional Recovery After Spinal Cord Injury in the Rat Cellular and Molecular Neurobiology. ,vol. 26, pp. 1165- 1178 ,(2006) , 10.1007/S10571-006-9093-1