Improvement of hydrogelation abilities and handling of photocurable gelatin-based crosslinking materials.

摘要: Three types of eosin-derivatized gelatins (eosin-gelatins) with different molecular weights (Mw) ca. 15 kDa (low-molecular-weight eosin-gelatin, LEG), 30 (medium-molecular-weight MEG), and 95 (high-molecular-weight HEG) were prepared. All the eosin-gelatins except for HEG dissolved completely in water at 37°C within several hours even high concentrations 35 or 40 wt % along polyamine (poly(N,N-dimethylaminopropylacrylamide)) to produce photo-crosslinkable materials. The materials had appropriate viscosity situ molding could be handled as a liquid low temperatures up 25°C. Upon photoirradiation tens seconds, converted almost hydrogels desired form microporous network structure by radical coupling reaction. mechanical strength produced controlled selecting particular weight concentration eosin-gelatins. obtained from LEG (40 %) MEG (35 elasticity similar that goat periodontal tissue. handling room temperature their photogelation ability drastically improved reducing Mw eosin-gelatin. potential usefulness regeneration has been discussed. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater,