作者: Antonio Daniel Barbosa , David B Savage , Symeon Siniossoglou
DOI: 10.1016/J.CEB.2015.04.017
关键词: Membrane biogenesis 、 Cell biology 、 Biology 、 Cellular homeostasis 、 Lipid droplet 、 Endoplasmic reticulum 、 Lipid metabolism 、 Mitochondrion 、 Organelle
摘要: Cellular homeostasis depends on the precisely coordinated use of lipids as fuels for energy production, building blocks membrane biogenesis or chemical signals intra-cellular and inter-cellular communication. Lipid droplets (LDs) are universally conserved dynamic organelles that can store mobilize fatty acids other lipid species their multiple cellular roles. Increasing evidence suggests contact zones between LDs play important roles in trafficking regulation metabolism. Here we review recent advances regarding nature functional relevance interactions organelles-particularly endoplasmic reticulum (ER), LDs, mitochondria vacuoles-that highlight importance