Lipid droplet–organelle interactions: emerging roles in lipid metabolism

作者: Antonio Daniel Barbosa , David B Savage , Symeon Siniossoglou

DOI: 10.1016/J.CEB.2015.04.017

关键词: Membrane biogenesisCell biologyBiologyCellular homeostasisLipid dropletEndoplasmic reticulumLipid metabolismMitochondrionOrganelle

摘要: Cellular homeostasis depends on the precisely coordinated use of lipids as fuels for energy production, building blocks membrane biogenesis or chemical signals intra-cellular and inter-cellular communication. Lipid droplets (LDs) are universally conserved dynamic organelles that can store mobilize fatty acids other lipid species their multiple cellular roles. Increasing evidence suggests contact zones between LDs play important roles in trafficking regulation metabolism. Here we review recent advances regarding nature functional relevance interactions organelles-particularly endoplasmic reticulum (ER), LDs, mitochondria vacuoles-that highlight importance

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