An Inflammatory Polymorphisms Risk Scoring System for the Differentiation of Ischemic Stroke Subtypes

摘要: Inflammation has been associated with atherothrombotic stroke and recently cardioembolic stroke. Different genetic risk factors have specifically the subtypes of ischemic (cardioembolic, atherothrombotic, lacunar). However, there are no studies that generated scores for different using polymorphisms inflammation. Methods. We analyzed 68 30 inflammatory mediator genes in 2,685 subjects: 1,987 cases 698 controls. a scoring system most significant weighted by odds ratio every polymorphism taken into consideration subtype. Results. Three polymorphisms, rs1205 (CRP gene), rs1800779, rs2257073 (NOS3 were ( value ). The score was only subtype value: 0.001) replicated an independent cohort 0.017). subjects highest presented 92.2% 0.002). Conclusion. genetics markers is more closely strokes than or lacunar strokes. could be useful prediction differentiation stroke; however, it might specific to particular subtypes.