Regulatory effects of dexamethasone on NK and T cell immunity.
作者： Liying Chen , Mikael Jondal , Konstantin Yakimchuk
DOI: 10.1007/S10787-017-0418-0
关键词: Immune system 、 Cancer research 、 Acquired immune system 、 Natural killer T cell 、 CD8 、 NKG2D 、 IL-2 receptor 、 Chemistry 、 Interleukin 21 、 Glucocorticoid receptor
摘要: Glucocorticoids (GCs) act via the intracellular glucocorticoid receptor (GR), which can regulate expression of target genes. With regard to immune system, GCs may affect both innate and adaptive immunity. Our study analyzed immunoregulatory effects dexamethasone (Dex) treatment on splenic T, Treg, NK NKT cells by treating C57Bl6 mice with various doses Dex. We observed that Dex decreased number in spleen suppressed their activity. In particular, Ly49G NKG2D receptors was However, did not population cells. T cells, our results show a dose-dependent reduction CD3+, CD4+, CD8+, CD44+ CD8+CD122+ but stimulatory effect CD4+CD25+ regulatory treatment. addition, anti-tumor response mouse EG7 tumor model. conclude suppress T- NK-mediated
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