Stereochemical factors in the transport and binding of photosensitizers in biological systems and in photodynamic therapy

摘要: Abstract The uptake and biological activity of porphyrins phthalocyanines in tumours were correlated with the geometrical features photosensitizer molecules. data suggest that a critical distance approximately 1.2 nm between oxygen atoms (originating SO 3 − , COO or OH substituents) characterizes biologically active for photodynamic therapy. We propose tubulin, which is available large amounts during mitosis, main receptor molecule binds these photosensitizers. Basic amino acid residues tightly bound cations tubulin homologous proteins may act as binding sites on molecule.