Botulinum toxin A for the treatment of delayed gastric emptying.

摘要: BACKGROUND Observational data suggest that intrapyloric injection of botulinum toxin A (BoTN/A) reduces symptoms and accelerates gastric emptying in idiopathic diabetic gastroparesis. Our purpose was to determine whether improves a significantly greater extent than placebo. An additional objective there is an acceleration after injection. METHODS single-institution, randomized, double-blind, placebo-controlled trial* done. Eligible patients had Gastroparesis Cardinal Symptom Index score > or = 27 with randomization toxin, 200 U (units), saline Reassessment repeat scan at 1-month follow-up were RESULTS Thirty-two randomized (N 16) placebo 16). At follow-up, 37.5% 56.3% achieved improvement as defined by this study. There no identifiable clinical predictors response. The group demonstrated emptying; however, not superior No serious adverse events attributable toxin. CONCLUSIONS Intrapyloric gastroparesis, although benefit 1 month. Also, comparison placebo, do improve month Overall, we are unable recommend therapy for widespread use the treatment delayed until more available.