Hereditary multiple exostoses and solitary osteochondroma associated with growth hormone deficiency: to treat or not to treat?

作者: Mauro Bozzola , Chiara Gertosio , Maria Gnoli , Federico Baronio , Elena Pedrini

DOI: 10.1186/S13052-015-0162-2

关键词: DiseaseGrowth hormone deficiencyOsteochondromaGenetic disorderMultiple exostosisPathologySingle lesionHereditary multiple exostosesMedicineSolitary Osteochondroma

摘要: Background Osteochondroma generally occurs as a single lesion and it is not heritable disease. When two or more osteochondroma are present, this condition represents genetic disorder named hereditary multiple exostoses (HME). Growth hormone deficiency (GHD) has rarely been found in HME patients few data about growth therapy (GH) effects development/growth of solitary have reported.

参考文章(25)
Kalliopi Stefanaki, Vassiliki Galani, Panagiotis Kitsoulis, Maria Bai, Niki John Agnantis, Georgios Paraskevas, Georgios Karatzias, Osteochondromas: review of the clinical, radiological and pathological features. in Vivo. ,vol. 22, pp. 633- 646 ,(2008)
Julianne Huegel, Federica Sgariglia, Motomi Enomoto-Iwamoto, Eiki Koyama, John P. Dormans, Maurizio Pacifici, Heparan sulfate in skeletal development, growth, and pathology: the case of hereditary multiple exostoses. Developmental Dynamics. ,vol. 242, pp. 1021- 1032 ,(2013) , 10.1002/DVDY.24010
HAMLET A. PETERSON, Multiple Hereditary Osteochondromata Clinical Orthopaedics and Related Research. ,vol. 239, pp. 222- 230 ,(1989) , 10.1097/00003086-198902000-00026
Elena Pedrini, Ivy Jennes, Morena Tremosini, Annamaria Milanesi, Marina Mordenti, Alessandro Parra, Federica Sgariglia, Monia Zuntini, Laura Campanacci, Nicola Fabbri, Elettra Pignotti, Wim Wuyts, Luca Sangiorgi, Genotype-phenotype correlation study in 529 patients with multiple hereditary exostoses: Identification of "protective" and "risk" factors Journal of Bone and Joint Surgery, American Volume. ,vol. 93, pp. 2294- 2302 ,(2011) , 10.2106/JBJS.J.00949
D. E. Porter, L. Lonie, M. Fraser, C. Dobson-Stone, J. R. Porter, A. P. Monaco, A. H. R. W. Simpson, Severity of disease and risk of malignant change in hereditary multiple exostoses: A GENOTYPE-PHENOTYPE STUDY Journal of Bone and Joint Surgery-british Volume. ,vol. 86, pp. 1041- 1046 ,(2004) , 10.1302/0301-620X.86B7.14815
C. Luckert Wicklund, R. M. Pauli, D. Johnston, J. T. Hecht, Natural history study of hereditary multiple exostoses. American Journal of Medical Genetics. ,vol. 55, pp. 43- 46 ,(1995) , 10.1002/AJMG.1320550113
E. LAZARO MARTINEZ, M. LEON SANZ, F. HAWKINS CARRANZO, Growth Hormone Deficiency Associated with Hereditary Multiple Exostoses – Growth Hormone Treatment of One Case Acta Paediatrica. ,vol. 77, pp. 218- 219 ,(2008) , 10.1111/J.1651-2227.1988.TB10840.X
Michael Chau, Julian C. Lui, Ellie B. M. Landman, Stephan-Stanislaw Späth, Andrea Vortkamp, Jeffrey Baron, Ola Nilsson, Gene Expression Profiling Reveals Similarities between the Spatial Architectures of Postnatal Articular and Growth Plate Cartilage PLoS ONE. ,vol. 9, pp. e103061- ,(2014) , 10.1371/JOURNAL.PONE.0103061
R C Hennekam, Hereditary multiple exostoses. Journal of Medical Genetics. ,vol. 28, pp. 262- 266 ,(1991) , 10.1136/JMG.28.4.262