Molecular imaging with nanoparticles: the dwarf actors revisited 10 years later

摘要: We explore present-day trends and challenges in nanomedicine. Creativity the laboratories continues: published literature on novel nanoparticles is now vast. Nanoagents are discussed here which composed entirely of strongly photoluminescent materials, tunable to desired optical properties inherently low toxicity. focus “quantum nanoparticles” prepared from allotropes carbon. The principles behind strong, photoluminescence quantum mechanical: we present them simple outline. major industries racing develop these materials can offer significant technical guidance nanomedicine, could help custom-design signalling nanoagents specifically for stated clinical applications. Since such agents small, they be targeted easily, making active targeting possible. consider it timely study interactions undergo with tissue components living animals learn understand overcome numerous barriers organism interposes between blood targets or parenchymal cells. As near infra-red spectrum opens up, detection glowing several centimeters deep a human subject becomes calculable way do this. Finally, discuss slow-fuse resource-inefficient entry into application. A first possible reason failure target across body’s barriers, see above. Second, sparse translational landscape funding support gaps yawn widely academic research subsequent development. agendas “stakeholders” participating this sad point some faint glimmers hope future.