Assessment of peripheral markers and ultrasonographic parameters in pregnant mares receiving intramuscular or intrauterine cloprostenol

作者: Giorgia Podico , Igor F. Canisso , Robyn E. Ellerbrock , Nicholas W. Dias , Vitor R.G. Mercadante

DOI: 10.1016/J.THERIOGENOLOGY.2019.09.025

关键词: GynecologyGestationTransrectal ultrasonographyEarly Pregnancy LossAbortionHeartbeatFetusRepeated measures designMedicinePregnancy

摘要: Abstract The present study aimed to compare two methods of prostaglandin-induced abortion in mares by determining blood markers (progesterone, estradiol-17β, alpha-fetoprotein, 13,14-dihydro-15-keto-prostaglandin-F2α (PGFM)), B-mode ultrasonographic parameters, and time until loss fetal heartbeat. It was hypothesized that intrauterine infusion cloprostenol results earlier compromise than intramuscular administration. Ovarian structures (number sizes follicles corpora lutea area), heartbeat, mobility thirteen singleton pregnancies were assessed daily transrectal ultrasonography induction pregnancy termination (60 ± 2 days gestation). Mares received 500 μg intramuscularly every 12 h (IM, n = 7) or once transcervically (TC, n = 6). After initial administration, examinations repeated at 6-h intervals heartbeat detected. Plasma progesterone, alpha-fetoprotein for five before after loss. In addition, plasma PGFM concentrations immediately administration (0 min), then 15, 30, 45 min, 1, 2, 3, 4, 6, Data analyzed using the MIXED procedure with measures SAS. Significance set P

参考文章(44)
Baker Cb, Woods Gl, Ball Ba, Erb Hn, Cooper Wl, Baldwin Jl, Mank Ec, Ley Wb, Bilinski J, Early pregnancy loss in brood mares. Journal of reproduction and fertility. ,vol. 35, pp. 455- ,(1987)
E. L. Squires, R. B. Hillman, B. W. Pickett, T. M. Nett, Induction of abortion in mares with equimate: effect on secretion of progesterone, PMSG and reproductive performance. Journal of Animal Science. ,vol. 50, pp. 490- 495 ,(1980) , 10.2527/JAS1980.503490X
Kindahl H, Lasley B, Daels Pf, Hughes Jp, Munro Cj, Stabenfeldt Gh, An oestrogen conjugate enzyme immunoassay for monitoring pregnancy in the mare: limitations of the assay between days 40 and 70 of gestation. Journal of reproduction and fertility. ,vol. 44, pp. 37- 44 ,(1991)
Barry A. Ball, Embryonic Loss in Mares: Incidence, Possible Causes, and Diagnostic Considerations Veterinary Clinics of North America: Equine Practice. ,vol. 4, pp. 263- 290 ,(1988) , 10.1016/S0749-0739(17)30641-7
L Krakowski, CH Krawczyk, K Kostro, T Stefaniak, F Novotny, J Obara, Serum levels of acute phase proteins: SAA, Hp and progesterone (P4) in mares with early embryonic death. Reproduction in Domestic Animals. ,vol. 46, pp. 624- 629 ,(2011) , 10.1111/J.1439-0531.2010.01715.X
M. A. Coutinho da Silva, I. F. Canisso, M. L. MacPherson, A. E. M. Johnson, T. J. Divers, Serum amyloid A concentration in healthy periparturient mares and mares with ascending placentitis Equine Veterinary Journal. ,vol. 45, pp. 619- 624 ,(2013) , 10.1111/EVJ.12034
J. Cuervo-Arango, J.J. Aguilar, M.L. Vettorazzi, R. Martínez-Boví, eCG concentrations, luteal structures, return to cyclicity, and postabortion fertility in embryo transfer recipient mares. Theriogenology. ,vol. 84, pp. 1003- 1013 ,(2015) , 10.1016/J.THERIOGENOLOGY.2015.05.038
Paccamonti Dl, Elective termination of pregnancy in mares. Javma-journal of The American Veterinary Medical Association. ,vol. 198, pp. 683- 689 ,(1991)
J. R. Crabtree, Y. Chang, A. M. de Mestre, Clinical presentation, treatment and possible causes of persistent endometrial cups illustrated by two cases Equine Veterinary Education. ,vol. 24, pp. 251- 259 ,(2012) , 10.1111/J.2042-3292.2011.00354.X
James I. Raeside, Heather L. Christie, Rudolf O. Waelchli, Keith J. Betteridge, Biosynthesis of oestrogen by the early equine embryo proper Reproduction, Fertility and Development. ,vol. 24, pp. 1071- 1078 ,(2012) , 10.1071/RD11275