Function of Nod-like receptors in microbial recognition and host defense
作者： Luigi Franchi , Neil Warner , Kyle Viani , Gabriel Nuñez
DOI: 10.1111/J.1600-065X.2008.00734.X
关键词: NOD2 、 Inflammasome 、 Proinflammatory cytokine 、 Signal transduction 、 NOD1 、 Cell biology 、 Innate immune system 、 Nod Signaling Adaptor Proteins 、 Biology 、 Caspase 1 、 Immunology 、 Immunology and Allergy
摘要: Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play critical role in the regulation host innate immune response. NLRs act as scaffolding assemble signaling platforms trigger nuclear factor-kappaB and mitogen-activated protein kinase pathways control activation inflammatory caspases. Importantly, mutations several members NLR family have been linked to variety diseases consistent with these molecules playing an important host-pathogen interactions In this review, we focus on Nod1 Nod2 defense particular discuss recent finding regarding Nlrc4, Nlpr1, Nlrp3 inflammasomes caspase-1 subsequent release proinflammatory cytokines such interleukin-1 beta.
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