Nanoparticle based strategies for the treatment of glioblastoma

摘要: Glioblastoma is the most common and biologically aggressive primary brain tumour in adults. In spite of tremendous investment into research which has led to development application novel diagnostic therapeutic measures management glioblastoma, prognosis still dismal with median survival time about 12 – 15 months. Also, success cytotoxic drugs clinically employed treatment glioblastoma greatly limited by their dose-limiting toxicity typically manifests as significant reduction blood cell counts. The aim this study demonstrate that a high dose nanoparticle formulation drug lomustine using self-assembling chitosan amphiphile, quaternary ammonium palmitoyl glycol would lead improved outcomes without commensurate increase toxic effects. based enabled administration (13 mg kg-1) 10 times higher than (1.2 achievable an ethanolic lomustine. Human bearing mice treated had mean 33.1 days while low 22.5 after intravenous once daily for consecutive days. increased (1.5 longer) resulting from was not accompanied gross Thus, afforded continuous schedule beneficial outcomes. addition, three peptide amphiphiles were synthesised characterised potential transport delivery molecules intracranial tumours.