Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51.
作者： Natalia M. Galigniana , Luzia T. Ballmer , Judith Toneatto , Alejandra G. Erlejman , Mariana Lagadari
DOI: 10.1111/J.1471-4159.2012.07775.X
关键词: Internal medicine 、 Hypothalamic–pituitary–adrenal axis 、 Endocrinology 、 Hsp90 、 Stress-related disorders 、 Glucocorticoid receptor 、 Mineralocorticoid 、 Immunophilins 、 Pharmacology 、 Receptor 、 Biology 、 Glucocorticoid
摘要: Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones affect steroid receptor function. Mood and anxiety disorders stress-related diseases characterized by an impaired function mineralocorticoid glucocorticoid receptors, two major regulatory elements hypothalamus-pituitary-adrenocortical axis. Genetic variations FK506-binding protein 51-kDa, FKBP51, one bound those complexes, were associated with effectiveness treatments against depression risk-factor for development post-traumatic stress disorders. Interestingly, show polymorphisms some polymorphic isoforms FKBP51 correlate greater impairment functions. In this review, we discuss different aspects role in such impact genetic variants immunophilin on dysregulation response.
sci-hub.se 参考文章(157)
Cordelia Schiene-Fischer, Tobias Aumüller, Gunter Fischer, Peptide Bond cis/trans Isomerases: A Biocatalysis Perspective of Conformational Dynamics in Proteins Topics in Current Chemistry. ,vol. 328, pp. 35- 67 ,(2011) , 10.1007/128_2011_151
E. Ronald De Kloet, Hormones, brain and stress Endocrine Regulations. ,vol. 37, pp. 51- 68 ,(2003)
J. G. Scammell, D. L. Valentine, C. M. Moore, P. D. Reynolds, J. A. Tucker, K. P. Roveda, Glucocorticoid-resistant B-lymphoblast cell line derived from the Bolivian squirrel monkey (Saimiri boliviensis boliviensis) Laboratory Animal Science. ,vol. 48, pp. 364- 370 ,(1998)
G Wiederrecht, S Hung, H.K. Chan, A Marcy, M Martin, J Calaycay, D Boulton, N Sigal, R.L. Kincaid, J.J. Siekierka, Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex. Journal of Biological Chemistry. ,vol. 267, pp. 21753- 21760 ,(1992) , 10.1016/S0021-9258(19)36676-1
Sara De Iudicibus, Raffaella Franca, Stefano Martelossi, Alessandro Ventura, Giuliana Decorti, None, Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease World Journal of Gastroenterology. ,vol. 17, pp. 1095- 1108 ,(2011) , 10.3748/WJG.V17.I9.1095
HR Quintá, MD Galigniana, The neuroregenerative mechanism mediated by the Hsp90‐binding immunophilin FKBP52 resembles the early steps of neuronal differentiation British Journal of Pharmacology. ,vol. 166, pp. 637- 649 ,(2012) , 10.1111/J.1476-5381.2011.01783.X
S. Tranguch, J. Cheung-Flynn, T. Daikoku, V. Prapapanich, M. B. Cox, H. Xie, H. Wang, S. K. Das, D. F. Smith, S. K. Dey, Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 14326- 14331 ,(2005) , 10.1073/PNAS.0505775102
W. Surs, S. J. Szefler, E. R. Sher, D. Y. M. Leung, J. C. Kam, Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids. Journal of Immunology. ,vol. 151, pp. 3460- 3466 ,(1993)
Mario D Galigniana, G Piwien Pilipuk, Activation of the Ligand–Mineralocorticoid Receptor Functional Unit by Ancient, Classical, and Novel Ligands. Structure–Activity Relationship Vitamins & Hormones. ,vol. 69, pp. 31- 68 ,(2004) , 10.1016/S0083-6729(04)69002-9
G. Fischer, T. Aumüller, Regulation of peptide bond cis/trans isomerization by enzyme catalysis and its implication in physiological processes Reviews of Physiology Biochemistry and Pharmacology. ,vol. 148, pp. 105- 150 ,(2003) , 10.1007/S10254-003-0011-3