KIBRA: a new gateway to learning and memory?
作者： Armin Schneider , Matthew J Huentelman , Joachim Kremerskothen , Kerstin Duning , Robert Spoelgen
DOI: 10.3389/NEURO.24.004.2010
关键词: Encoding (memory) 、 Computational biology 、 Bioinformatics 、 Single-nucleotide polymorphism 、 Functional studies 、 Cognitive impairment 、 Psychology 、 Function (biology) 、 Human memory 、 Gateway (computer program)
摘要: The genetic locus encoding KIBRA, a member of the WWC family proteins, has recently been shown to be associated with human memory performance through genome-wide single nucleotide polymorphism screening. Gene expression analysis and variety functional studies have further indicated that such role is biologically plausible for KIBRA. Here, we review existing literature, illustrate connections between different lines evidence, derive models based on KIBRA’s function(s) in brain can tested experimentally.
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