Effects of neuregulin‐1 genetic variation and depression symptom severity on longitudinal patterns of psychotic symptoms in primary care attendees

摘要: A better understanding of the factors associated with psychotic symptoms could aid early identification and treatment disorders. Previous studies have typically utilized cross-sectional study designs focused on individuals Thus, examination promising correlates using longitudinal among more broadly defined populations is warranted. Two such are neuregulin-1 (NRG1) genotypic variation depression symptom severity. Both NRG1 severity evidence for an association psychosis but their affect patterns potential interaction effects less clear. Using repeated measures analysis variance covariance we modeled main depressive in 301 primary care attendees assessed annually over 4 years. One-fifth (19.9%) participants reported one or 4-year assessment period. We observed a curvilinear (i.e., cubic) between at baseline did not observe effect patterns. However, rs6994992 genotype moderated Specifically, had carriers TT compared to CC CT carriers. Our findings suggest that by genotype. © 2013 Wiley Periodicals, Inc.