Ergosterol replacement of tetrahymanol in Tetrahymena membranes.
作者： R.L. Conner , F.B. Mellory , J.R. Landrey , K.A. Ferguson , E.S. Kaneshiro
DOI: 10.1016/0006-291X(71)90810-2
关键词: Tetrahymena 、 Phospholipid 、 Biology 、 Ciliary membrane 、 Tetrahymena pyriformis 、 Biochemistry 、 Growth medium 、 Ergosterol 、 Sterol 、 Membrane
摘要: Abstract The naturally occurring pentacyclic triterpene alcohol of Tetrahymena pyriformis , tetrahymanol, is replaced by ergosterol as a result supplementation the growth medium with that sterol. Since tetrahymanol not metabolized ciliate, loss from sterol-supplemented cells appears to occur through dilution during growth. Ergosterol-grown are at least 20 times more sensitive polyene antibiotics than normal cells. substitution for observed in whole also reflected isolated cilia and ciliary membrane preparations. In these membranes, phospholipid/tetrahymanol ratio similar phospholipid/ergosterol ration ergosterol-grown
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