Therapeutic Potential of Oligonucleotide-Based Therapy in Cardiovascular Disease

摘要: Molecular therapy is emerging as a potential strategy for the treatment of cardiovascular disease such restenosis after angioplasty, vascular bypass graft occlusion and transplant coronary vasculopathy, which no known effective exists. One combating has been to target transcriptional translational processes. Three approaches have used accomplish this. approach use antisense oligodeoxynucleotides (ODN) that are complimentary messenger RNA (mRNA) interest. The second ribozymes, unique class molecules not only store information but also possess catalytic activity. Ribozymes catalytically cleave specific species, leading their degradation, whereas inhibit translation by binding mRNA sequences on stoichiometric basis. Thus, theoretically, ribozymes more in inhibiting target-gene expression. A third transfection cis-element double-stranded decoy ODN. Transfection ODN will result attenuation authentic cis-trans interaction, removal trans-factors from endogenous cis-elements, with subsequent modulation gene This novel promises therapeutic represents powerful tool study regulation vivo well vitro. In particular, early work relating appears promising. application DNA-based therapies regulate transcription disease-related genes important potential.