Corticotropin-releasing hormone and arginine vasopressin in depression focus on the human postmortem hypothalamus.

摘要: Abstract The neuropeptides corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are crucially involved in the pathogenesis of depression. close correlation between etiology depression dysregulation stress responses is based upon a hyperactivity hypothalamo–pituitary–adrenal (HPA) axis. CRH neurons paraventricular nucleus motor HPA-axis. Centrally released CRH, AVP, increased levels cortisol all contribute to signs symptoms Single-nucleotide polymorphisms AVP receptor genes associated with risk for Activation HPA-axis generally regarded be final common pathway Sex hormones regulation gene expression. decreased activity biological clock, suprachiasmatic nucleus, as indicated by its lower expression, basis disturbed rhythms Both similarities differences found changes systems depressive disorders Alzheimer's disease.