Sialic acids as ligands in recognition phenomena.

摘要: The sialic acids are acidic monosaccharides typically found at the outermost ends of sugar chains animal glycoconjugates. They potentially can inhibit intermolecular and intercellular interactions by virtue their negative charge. However, they also act as critical components ligands recognized a variety proteins animal, plant, microbial origin (sialic acid binding lectins). Recognition be affected specific structural variations modifications acids, linkage to underlying chain, structure these chains, nature glycoconjugate which attached. Presented here is summary various that recognize bind this family monosaccharides, comparing contrasting requirements mechanisms involved in binding. Particular attention focused on recently evolving information about recognition certain C-type lectins (the selectins), I-type (e.g., CD22 a...