Coordination of Hox identity between germlayers along the anterior-to-posterior axisof the vertebrate embryo

摘要: During early embryonic development, a relatively undifferentiated mass of cells is shaped into complex and morphologically differentiated embryo. This is achieved by series coordinated cell movements that end up in the formation three germ layers most metazoans establishment body plan. Hox genes are among main determinants this process they have prominent role in granting identity to different regions The particular arrangement of their expression domains development corresponds characterises several future structures older embryo adult animal. Getting know molecular cellular phenomena underlying correct Hox pattern will help us understand how complexity fully-formed organism can arise from its raw materials, fertilised egg (zygote) and large but apparently limited repertoire agents. In present work I concentrated on specific factors, their mechanism action, set patterns gastrula and neurula put special emphasis initiation expression, which takes place first non-organiser mesoderm subsequently the neuroectoderm. investigated retinoid signalling found it is required during late gastrulation for activation 3’ genes Furthermore, show evidence earliest phase expression in requires Wnt, not retinoid, activity. Moreover, the most are direct targets Wnt pathway, whereas other indirectly regulated. Finally, provide preliminary results suggest potential mechanism communication between and neuroectoderm mediated by HOX protein intercellular signalling. phenomenon would enable coordination pattern two tissues.