Twice-weekly fluconazole prophylaxis in premature infants: Association with cholestasis

作者: Vishwanath Bhat , Milliecor Fojas , Judy G. Saslow , Sahil Shah , Sulaiman Sannoh

DOI: 10.1111/J.1442-200X.2010.03286.X

关键词: Invasive candidiasisRegimenDosingAnesthesiaIncidence (epidemiology)PediatricsFluconazoleCholestasisDemographicsMedicineSignificant differencePediatrics, Perinatology, and Child Health

摘要: Background:  Fluconazole prophylaxis is effective in preventing invasive candidiasis extremely low-birthweight (ELBW) infants. The authors previously reported an increased incidence of cholestasis with fluconazole ELBW infants, which led to being changed a less frequent dosing (LFD) schedule twice week at their institution. purpose the present study was therefore evaluate effectiveness and safety LFD infants. Methods:  infants who received regimen (twice for up 6 weeks) were compared (FD) (every 72 h first 2 weeks, every 48 h next weeks 24 h final weeks). two groups baseline demographics, risk factors candidiasis, rate fungal infection severity cholestasis. Results:  There no significant difference (2/104, 2%) FD (0/140, 0%; P= 0.4) prophylaxis. lower trend towards decreased observed on schedule. Conclusion:  schedule.

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