Taming Cell Penetrating Peptides: Never Too Old To Teach Old Dogs New Tricks.
作者： Qianyu Zhang , Huile Gao , Qin He
DOI: 10.1021/ACS.MOLPHARMACEUT.5B00428
关键词: Drug delivery 、 Amino acid 、 Delivery efficiency 、 Combinatorial chemistry 、 Cell 、 Medicine 、 Improved performance 、 Biochemistry
摘要: Cell penetrating peptides (CPPs) have received substantial attention due to their intrinsic property cross plasma membranes or even as helpers facilitate the cellular entry of drug molecules, macromolecules, and nanoparticles. Although CPPs CPP-like provided versatile platforms for delivery, nonselectivity lack delivery efficiency is stirring up debates tactics optimizing themselves. The good news that, spurred by recent progress in understanding tumor microenvironment well biochemistry material sciences, we made attempts working on perfecting “taming” CPP-functionalized vectors some them afforded gratifying results. Due fact that these are mainly short amino acids (5–30 acids), addition, modification, replacement might lead surprisingly improved performance. Several novel environment-responsive...
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sci-hub.se 参考文章(155)
Kelly M. Stewart, Kristin L. Horton, Shana O. Kelley, Cell-penetrating peptides as delivery vehicles for biology and medicine Organic and Biomolecular Chemistry. ,vol. 6, pp. 2242- 2255 ,(2008) , 10.1039/B719950C
Eun Seong Lee, Zhonggao Gao, Dongin Kim, Kyeongsoon Park, Ick Chan Kwon, You Han Bae, Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance Journal of Controlled Release. ,vol. 129, pp. 228- 236 ,(2008) , 10.1016/J.JCONREL.2008.04.024
Moritoshi Higa, Chiaki Katagiri, Chigusa Shimizu-Okabe, Tomoyuki Tsumuraya, Masanori Sunagawa, Mariko Nakamura, Shogo Ishiuchi, Chitoshi Takayama, Eisaku Kondo, Masayuki Matsushita, Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a cancer-homing transporter. Biochemical and Biophysical Research Communications. ,vol. 457, pp. 206- 212 ,(2015) , 10.1016/J.BBRC.2014.12.089
Hiroto Hatakeyama, Erika Ito, Hidetaka Akita, Motoi Oishi, Yukio Nagasaki, Shiroh Futaki, Hideyoshi Harashima, A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. Journal of Controlled Release. ,vol. 139, pp. 127- 132 ,(2009) , 10.1016/J.JCONREL.2009.06.008
S. Deshayes, M. C. Morris, G. Divita, F. Heitz, Cell-penetrating peptides: tools for intracellular delivery of therapeutics. Cellular and Molecular Life Sciences. ,vol. 62, pp. 1839- 1849 ,(2005) , 10.1007/S00018-005-5109-0
Elamprakash N. Savariar, Csilla N. Felsen, Nadia Nashi, Tao Jiang, Lesley G. Ellies, Paul Steinbach, Roger Y. Tsien, Quyen T. Nguyen, Real-time In Vivo Molecular Detection of Primary Tumors and Metastases with Ratiometric Activatable Cell-Penetrating Peptides Cancer Research. ,vol. 73, pp. 855- 864 ,(2013) , 10.1158/0008-5472.CAN-12-2969
Quanyin Hu, Guangzhi Gu, Zhongyang Liu, Mengyin Jiang, Ting Kang, Deyu Miao, Yifan Tu, Zhiqing Pang, Qingxiang Song, Lei Yao, Huimin Xia, Hongzhan Chen, Xinguo Jiang, Xiaoling Gao, Jun Chen, F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug delivery Biomaterials. ,vol. 34, pp. 1135- 1145 ,(2013) , 10.1016/J.BIOMATERIALS.2012.10.048
Seong Loong Lo, Shu Wang, An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection. Biomaterials. ,vol. 29, pp. 2408- 2414 ,(2008) , 10.1016/J.BIOMATERIALS.2008.01.031
Hannah Schröder-Borm, Rumiana Bakalova, Jörg Andrä, The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine. FEBS Letters. ,vol. 579, pp. 6128- 6134 ,(2005) , 10.1016/J.FEBSLET.2005.09.084
Wei Zhang, Jingjing Song, Bangzhi Zhang, Liwei Liu, Kairong Wang, Rui Wang, Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells. Bioconjugate Chemistry. ,vol. 22, pp. 1410- 1415 ,(2011) , 10.1021/BC200138D