The hepatocyte growth factor receptor (MET): An unconventional transducer of mitogenic and motogenic signals

摘要: Publisher Summary Hepatocyte growth factor (HGF) is a potent mitogen with misleading name. It stimulates in parenchymal liver cells and variety of epithelial nonepithelial including skin keratinocytes, melanocytes, kidney tubules. Moreover, HGF endothelial vitro, it powerful angiogenic “in vivo”. The meaning the acronym consistent fact that this is, nonetheless, major mediator regeneration vivo essential for development embryo. has chemotactic properties dissociates cell layers, increasing their motility invasiveness into extracellular matrices. induces spread carcinoma vitro promotes progression toward malignant invasive phenotype. Because these unique properties, also called “scatter factor.” Paradoxically, other name once used to identify was “sarcoma necrosis factor” its growth-inhibitory effect on some tumor lines mesenchymal origin. Lastly, adding or grown three-dimensional collagen networks tubule formation showing effective morphogenic activity. When added embryonal progenitor cells, differentiation primordial biliary-like tubular structures.