Frequency tuning of cochlear hair cells by differential splicing of BK channel transcripts.

摘要: Hearing sense organs, though somewhat variable among species in cellular organization and disposition, all utilize mechanically sensitive receptor hair cells to accomplish the transduction of acoustic stimuli into electrical activity which informs brain. The frequency components complex are resolved spatially encoded by peripheral organ; this tonotopic information is preserved addressed through several relay nuclei pathway auditory cortex. Frequency analysis performed organ using mechanisms either extrinsic, or intrinsic, cell. It generally agreed that basilar membrane, upon sit, major component analyser mammalian Corti. Sounds different frequencies maximally displace membrane at locations, resulting differential stimulation population cells. tuned boosted feedback from outer cells, thereby filters stimulus, so a given cell exposed only narrow range frequencies. In number lower vertebrates, however, poorly not predominantly task themselves.