Determination of Atorvastatin Pharmacokinetic Parameters by LC/MS-MS with Traditional Liquorice Beverage
作者： Teeba Al Shaikhli , Wael Abu Dayyih , Eyad Mallah , Mohammed Hamad , Nidal Qinna
DOI:
关键词: Pharmacology 、 Chemistry 、 Atorvastatin 、 Chromatography 、 Lc ms ms 、 Glimepiride 、 Cmax 、 Autosampler 、 Injection volume 、 Formic acid 、 Pharmacokinetics
摘要: s The objective of this randomized controlled study was firstly, developing and validating a simple simultaneous LC/MS method to quantify Atorvastatin in rat serum. Secondly, investigating the effects Liquorice fresh beverage on pharmacokinetics serum rats. determined rat's plasma using high resolution, sensitivity validated Liquid Chromatography–Mass Spectrometry (LC-MS); mobile phase (75% methanol, 25% 0.2% Formic acid water), ACE 5 C8 Column (50 X 2.1 mm, 5µ), 1.0 ml/min flow rate, microliters Autosampler injection volume, Glimepiride as an internal standard. analytical linear with acceptable recovery, precision accuracy. A significant (P 0.05) single dose juice Cmax (29.847 ng/ml), repeated doses (40.113 ng/ml) which is also considered non- effect (P>0.05) We conclude that varies between can be result could affect pharmacokinetics.
sapub.org参考文章(29)
T. K. Lim, Citrus x aurantium Grapefruit Group Edible Medicinal And Non-Medicinal Plants. pp. 755- 785 ,(2012) , 10.1007/978-94-007-4053-2_91
Srinivas Guptha Gunturu, T. S. Dharmarajan, T. S. Dharmarajan, T. S. Dharmarajan, T. S. Dharmarajan, Drug–Nutrient Interactions Geriatric Gastroenterology. pp. 89- 98 ,(2012) , 10.1007/978-1-4419-1623-5_10
Vinod P Shah, Kamal K Midha, John WA Findlay, Howard M Hill, James D Hulse, Iain J McGilveray, Gordon McKay, Krys J Miller, Rabindra N Patnaik, Mark L Powell, Alfred Tonelli, CT Viswanathan, Avraham Yacobi, Bioanalytical method validation--a revisit with a decade of progress. Pharmaceutical Research. ,vol. 17, pp. 1551- 1557 ,(2000) , 10.1023/A:1007669411738
Ichiro Fukazawa, Naoki Uchida, Eiji Uchida, Hajime Yasuhara, Effects of grapefruit juice on pharmacokinetics of atorvastatin and pravastatin in Japanese British Journal of Clinical Pharmacology. ,vol. 57, pp. 448- 455 ,(2004) , 10.1046/J.1365-2125.2003.02030.X
Danny D. Shen, Kenneth E. Thummel, James D. Perkins, Christopher L. Marsh, Mary F. Paine, Mehraneh Khalighi, Jeannine M. Fisher, Kent L. Kunze, Characterization of Interintestinal and Intraintestinal Variations in Human CYP3A-Dependent Metabolism Journal of Pharmacology and Experimental Therapeutics. ,vol. 283, pp. 1552- 1562 ,(1997)
Nathalie Le Goff-Klein, Jean-Claude Koffel, Louis Jung, Geneviève Ubeaud, In vitro inhibition of simvastatin metabolism, a HMG-CoA reductase inhibitor in human and rat liver by bergamottin, a component of grapefruit juice. European Journal of Pharmaceutical Sciences. ,vol. 18, pp. 31- 35 ,(2003) , 10.1016/S0928-0987(02)00222-1
Christina S. Won, Nicholas H. Oberlies, Mary F. Paine, Mechanisms Underlying Food-Drug Interactions: Inhibition of Intestinal Metabolism and Transport Pharmacology & Therapeutics. ,vol. 136, pp. 186- 201 ,(2012) , 10.1016/J.PHARMTHERA.2012.08.001
Joseph I. Boullata, Lauren M. Hudson, Drug–Nutrient Interactions: A Broad View with Implications for Practice Journal of the Academy of Nutrition and Dietetics. ,vol. 112, pp. 506- 517 ,(2012) , 10.1016/J.JADA.2011.09.002
Furquan Nazimuddin Khan, Mohamed Hassan G. Dehghan, Enhanced Bioavailability of Atorvastatin Calcium from Stabilized Gastric Resident Formulation Aaps Pharmscitech. ,vol. 12, pp. 1077- 1086 ,(2011) , 10.1208/S12249-011-9673-3
Angelo A. Izzo, Interactions between Herbs and Conventional Drugs: Overview of the Clinical Data Medical Principles and Practice. ,vol. 21, pp. 404- 428 ,(2012) , 10.1159/000334488