α1- and α2-adrenoceptors in the smooth muscle of isolated rabbit urinary bladder and urethra
作者： Shoichi Ueda , Nobuhiro Satake , Shoji Shibata
DOI: 10.1016/0014-2999(84)90484-9
关键词: Propranolol 、 Phenylephrine 、 Urethra 、 Internal medicine 、 Yohimbine 、 Trigone of urinary bladder 、 Endocrinology 、 Urinary bladder 、 Urinary system 、 Chemistry 、 Prazosin
摘要: The present experiment was undertaken to determine the existence of alpha 1- and 2-adrenoceptors in smooth muscle rabbit bladder dome, trigone proximal urethra. In dome pretreated with propranolol (10(-6) M), phenylephrine (10(-5) M-10(-3) M) norepinephrine (10(-7) M-10(-5) caused only a small contraction but norepinephrine, at high concentrations (10(-4) produced relaxation. Clonidine, however, had no effect on dome. both urethra, phenylephrine, clonidine dose-dependent contractions. contractile response or significantly greater than that such difference observed Prazosin (10(-8) M-10(-6) M, 1-adrenoceptor antagonist) rightward shift dose-response curve Yohimbine 2-adrenoceptor inhibited without affecting responses phenylephrine. These studies indicated are 1-adrenoceptors sparsely distributed.
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