The influence of poly(ester amide) on the structural and functional features of 3D additive manufactured poly(ε-caprolactone) scaffolds.

摘要: Abstract The current research reports for the first time use of blends poly(e-caprolactone) (PCL) and poly(ester amide) (PEA) fabrication 3D additive manufactured scaffolds. Tailor made PEA was synthesized to afford fully miscible PCL using different percentages (5, 10, 15 20% w/w). Stability, characteristic temperatures material's compatibility were studied through thermal analyses (i.e., TGA, DSC). Even though DMTA static compression tests demonstrated possibility improve storage modulus, Young's modulus maximum stress by increasing amount PEA, a decrease hardness found beyond threshold concentration as lowest values achieved PCL/PEA (20% w/w) scaffolds (from 0.39 ± 0.03 GPa 0.21 ± 0.02 GPa in analysed load range). presented controlled morphology interconnected network internal channels. water contact angle measurements showed clear increase hydrophilicity resulting from addition PEA. This result further corroborated with improved adhesion proliferation human mesenchymal stem cells (hMSCs). presence also influenced cell morphology. Better spreading much higher homogenous number observed when compared ones.