High Viral Eradication with a Daily 12-Week Natural Interferon-β Treatment Regimen in Chronic Hepatitis C Patients with Low Viral Load

摘要: Virological sustained response (SR) is achieved in 31–49% of patients with chronic hepatitis C combination therapy using interferon (IFN) -α and ribavirin for 24–48 weeks. However, as a period weeks burden patients, we investigated the effect daily intravenous administration natural IFN-β 12 this study. In all, 112 were enrolled received 6 MU intravenously Serum HCV-RNA before treatment was assessed by competitive reverse-transcription polymerase chain reaction assay. The divided into two groups according to pretreatment viral load: low load group (N = 25, <6.3 × 105 copies/ml), high 87, ≥6.3 copies/ml) who additionally administered thrice weekly subsequent 14 at patients' request. SR obtained 37% (41/112) all patients; 88% those load, 22% load. attained 21% HCV subtype 1, 67% 2a. 1b, virological mutant-type (≥4 amino acid mutations NSSA2209–48) having (4/4), but not (0/3). results suggest that showed therapeutic efficacy despite shorter depends on rather than number NS5A2209–48 mutations.