Interfering with the dynamics of estrogen receptor-regulated transcription.

摘要: In recent years, there has been a growing realization that static two-dimensional model of gene activation by transcription factors is inadequate. Based on the work from number groups (Kang et al. 2002; Liu and Bagchi 2004; Metivier 2003; Park 2005; Reid Shang 2000; Sharma Fondell Vaisanen 2005), it becoming clear transcriptional regulation nuclear receptors dynamic cyclical process (Metivier 2006). There are significant consequences arise this shift in understanding, as ligand activated bind to response element activate expression target where receptor repeatedly binds order achieve transcription. New insights viewing for developing new strategies modulate activity estrogen outlined chapter.