Effective size and polymorphism of linked neutral loci in populations under directional selection.

摘要: The general theory of the effective size (Ne) for populations under directional selection is extended to cover linkage. Ne a function association between neutral and selected genes generated by finite sampling. This reduced three factors: recombination rate, reduction genetic variance due drift, selection. If genome (L in Morgans) not extremely small equation [formula, see text] where N number reproductive individuals, C 2 fitness scaled squared mean fitness, (1 - Z) = Vm/C2 rate variation per generation Vm mutational input fitness. above predictive valid infinitesimal model detrimental mutations. principles are also applicable favorable mutation models if there continuous flux advantageous predictions tested simulation, connection with previous results found discussed. associated progressive over generations until asymptotic value (the expression) reached after generations. magnitude drift process is, therefore, smaller recent mutations than old ones. produces equilibrium values average heterozygosity proportion segregating sites that cannot be formally predicted from Ne, but both parameters can still following along lineage genes. spectrum gene frequencies given considering overlapping distributions corresponding arose different sizes.