Fatigue symptoms in relation to neuroticism, anxiety-depression, and musculoskeletal pain. A longitudinal twin study

摘要: Background The nature of the relationship between fatigue and its risk factors is poorly understood. In present study genetic environmental association anxiety-depression, musculoskeletal (MS) pain was examined, role neuroticism as a shared factor that may possibly explain co-occurrence these phenotypes investigated in combined cross-sectional longitudinal twin design. Methods sample consisted 746 monozygotic (MZ) 770 dizygotic (DZ) twins age group 50-65 (mean = 57.11 years, SD 4.5). Continuous measures symptoms other were employed. Using Cholesky modeling, influences on phenotypes, associations among them, determined. Analyses performed using obtained concurrently 13-19 years earlier. Results from multiple regression analyses showed neuroticism, anxiety-depression symptoms, MS all significantly associated with fatigue, controlling for sex, education, general health indices. best-fitting biometric models included additive individual-specific effects. Heritabilities 0.40-0.53 range demonstrated. Furthermore, while there considerable overlap four substantial proportion independent neuroticism. Conclusion Evidence common underlying susceptibility to report genetically linked pain, found. Both unique pleiotropic effects appear be involved architecture phenotypes.