Expression of Somatostatin, cortistatin, and their receptors, as well as dopamine receptors, but not of neprilysin, are reduced in the temporal lobe of Alzheimer's disease patients.

摘要: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive deficit, wherein the impairment of episodic memory major hallmark. AD patients exhibit augmented accumulation amyloid-beta (Abeta) and hyperphosphorylated tau protein in specific brain regions. In addition, several neuropeptides/neurotransmitter axes clearly associated with processes, Abeta turnover, phosphorylation have also been found to be impaired AD, such as somatostatin (SST)/cortistatin (CST) dopamine (DA) systems. However, date there no precise quantitative data on expression these systems human normal patients. Here we measured real-time PCR mRNA levels SST/CST, their receptors (sst1-5 DA (drd1-5) addition neprilysin (a SST-regulated enzyme involved degradation) three regions temporal lobe, one cortical most severely affected AD. Our results reveal that some components SST/CST- DA-axes are divergently altered areas Despite this region-specific regulation, an overall, common reduction was observed lobe Conversely, not suggesting due lack activation SST rather than its expression. Collectively, our define comprehensive scenario ssts, drds, sst ligands CST, could involved, at least part, more important defects