Toward systems neuroscience in mild cognitive impairment and Alzheimer's disease: A meta‐analysis of 75 fMRI studies

摘要: Most of the previous task functional magnetic resonance imaging (fMRI) studies found abnormalities in distributed brain regions mild cognitive impairment (MCI) and Alzheimer's disease (AD), few investigated network dysfunction from system level. In this meta-analysis, we aimed to examine MCI AD. We systematically searched task-based fMRI AD published between January 1990 2014. Activation likelihood estimation meta-analyses were conducted compare significant group differences activation, voxels overlaid onto seven referenced neuronal cortical networks derived resting-state data 1,000 healthy participants. Thirty-nine (697 patients 628 controls) included MCI-related meta-analysis while 36 (421 512 AD-related meta-analysis. The meta-analytic results revealed that showed abnormal regional activation as well large-scale networks. hypoactivation default, frontoparietal, visual relative controls, whereas mainly located visual, ventral attention controls. Both hyperactivation fell attention, somatomotor presented different pathological shared similar compensatory fulfilling tasks. These system-level findings are helpful link fundamental declines tasks