Hot-melt extrusion – basic principles and pharmaceutical applications
作者： Bo Lang , James W. McGinity , Robert O. Williams
DOI: 10.3109/03639045.2013.838577
关键词: Pharmaceutical industry 、 Engineering 、 Process engineering 、 Extrusion 、 Process development 、 Plastics industry 、 Hot melt 、 Melt extrusion
摘要: AbstractOriginally adapted from the plastics industry, use of hot-melt extrusion has gained favor in drug delivery applications both academia and pharmaceutical industry. Several commercial products made by have been approved FDA, demonstrating its feasibility for processing. A significant number research articles reported on advances regarding processing; however, only limited focused general principles formulation process development. This review provides an in-depth analysis discussion processing aspects extrusion. The impact physicochemical properties substances excipients development using a is discussed material science point view. Hot-melt development, scale-up, interplay att...
sci-hub.se 参考文章(186)
David B. Todd, Plastics compounding : equipment and processing Hanser Publishers. ,(1998)
Patrick J. Sinko, Alfred N. Martin, Yashveer Singh, Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences Wolters Kluwer Health/Lippincott Williams & Wilkins. ,(2011)
Bruno C. Hancock, Sheri L. Shamblin, George Zografi, Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharmaceutical Research. ,vol. 12, pp. 799- 806 ,(1995) , 10.1023/A:1016292416526
L. H. Sperling, Introduction to physical polymer science ,(1986)
G. Hinrichsen, Introduction to physical polymer science (2nd ed.). By L. H. Sperling, Lehigh University, Bethlehem, Pennsylvania. John Wiley & Sons, Inc., New York, 1992. Acta Polymerica. ,vol. 44, pp. 110- 110 ,(1993) , 10.1002/ACTP.1993.010440213
Carolyn Aitken‐Nichol, Feng Zhang, James W. McGinity, Hot melt extrusion of acrylic films Pharmaceutical Research. ,vol. 13, pp. 804- 808 ,(1996) , 10.1023/A:1016076306279
Rodolfo Pinal, Markus Thommes, Teresa M. Carvajal, Solid formulations of crystalline compounds ,(2008)
Ashish Chatterji, Navnit Hargovindas Shah, Harpreet K. Sandhu, Dave Alan Miller, Dipen Desai, A process for controlled crystallization of an active pharmaceutical ingredient from supercooled liquid state by hot melt extrusion ,(2012)
Allen E. Moton, Russell C. Prestipino, Jiansheng Wan, Marc Steinman, Larry Yun Fang, Gopal Krishna, Hetty Anne Waskin, David Harris, High density compositions containing posaconazole and formulations comprising the same ,(2009)
Gavin P. Andrews, Osama Abu-Diak, Febe Kusmanto, Peter Hornsby, Zhai Hui, David S. Jones, Physicochemical characterization and drug-release properties of celecoxib hot-melt extruded glass solutions Journal of Pharmacy and Pharmacology. ,vol. 62, pp. 1580- 1590 ,(2010) , 10.1111/J.2042-7158.2010.01177.X