作者: Yoshihiro Noda , Reza Zomorrodi , Takashi Saeki , Tarek K. Rajji , Daniel M. Blumberger
DOI: 10.1016/J.CLINPH.2016.12.023
关键词: Hamilton Rating Scale for Depression 、 Dorsolateral 、 Audiology 、 Beck Depression Inventory 、 Cognition 、 Transcranial magnetic stimulation 、 Neuroscience 、 Psychology 、 Wisconsin Card Sorting Test 、 Depression (differential diagnoses) 、 Electroencephalography
摘要: Abstract Objective We aimed to investigate neuromodulatory effects of high-frequency left dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation (rTMS) on resting-state electroencephalography (EEG) and their clinical cognitive correlates in patients with depression. Methods Thirty-one diagnosed depression included the present study. Resting-state gamma power theta–gamma coupling (TGC) were calculated before after a course rTMS. explored relationship among power, TGC, clinical/cognitive outcomes as measured Hamilton Rating Scale for Depression (HAM-D 17 ), Beck Inventory (BDI), Wisconsin Card Sorting Test (WCST). Results Following rTMS, depressed demonstrated significant increases resting at F3 F4 electrode sites TGC C3 T3 sites. Furthermore, increased site was significantly correlated improved score HAM-D BDI, while reduced number errors WCST. Conclusion Thus, may represent potential biomarkers associated therapeutic Significance EEG provide related