Treating hearing loss
作者： Albert Edge , Kunio Mizutari , Masato Fujioka , Hideyuki Okano
DOI:
关键词: Medicine 、 Audiology 、 Hearing loss 、 Noise exposure 、 Gamma secretase
摘要: This invention relates to methods for treating hearing loss associated with of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, adolescents and adults.
lens.org 参考文章(189)
Andreas Hermann, Regina Gastl, Stefan Liebau, M Oana Popa, Jörg Fiedler, Bernhard O Boehm, Martina Maisel, Holger Lerche, Johannes Schwarz, Rolf Brenner, Alexander Storch, Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells. Journal of Cell Science. ,vol. 117, pp. 4411- 4422 ,(2004) , 10.1242/JCS.01307
Thomas Vierbuchen, Austin Ostermeier, Zhiping P. Pang, Yuko Kokubu, Thomas C. Südhof, Marius Wernig, Direct conversion of fibroblasts to functional neurons by defined factors Nature. ,vol. 463, pp. 1035- 1041 ,(2010) , 10.1038/NATURE08797
Kazuo Oshima, Kunyoo Shin, Marc Diensthuber, Anthony W. Peng, Anthony J. Ricci, Stefan Heller, Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem Cells Cell. ,vol. 141, pp. 704- 716 ,(2010) , 10.1016/J.CELL.2010.03.035
C. S. Chim, L. G. Wong, Deafness associated with the use of Bortezomib in multiple myeloma Acta Oncologica. ,vol. 47, pp. 323- 324 ,(2008) , 10.1080/02841860701558823
Eva Y. Ma, David W. Raible, Signaling Pathways Regulating Zebrafish Lateral Line Development Current Biology. ,vol. 19, ,(2009) , 10.1016/J.CUB.2009.03.057
Dominik Brors, Daniel Bodmer, Kwang Pak, Christoph Aletsee, Maria Schäfers, Stefan Dazert, Allen F. Ryan, EphA4 provides repulsive signals to developing cochlear ganglion neurites mediated through ephrin-B2 and -B3. The Journal of Comparative Neurology. ,vol. 462, pp. 90- 100 ,(2003) , 10.1002/CNE.10707
Mark A. Parker, Biotechnology in the treatment of sensorineural hearing loss: foundations and future of hair cell regeneration. Journal of Speech Language and Hearing Research. ,vol. 54, pp. 1709- 1731 ,(2011) , 10.1044/1092-4388(2011/10-0149)
P. Jaakkola, D. R. Mole, Y.-M. Tian, M. I. Wilson, J. Gielbert, S. J. Gaskell, A. v. Kriegsheim, H. F. Hebestreit, M. Mukherji, C. J. Schofield, P. H. Maxwell, C. W. Pugh, P. J. Ratcliffe, Targeting of HIF-alpha to the von Hippel-Lindau Ubiquitylation Complex by O2-Regulated Prolyl Hydroxylation Science. ,vol. 292, pp. 468- 472 ,(2001) , 10.1126/SCIENCE.1059796
Sovana Adhikary, Federica Marinoni, Andreas Hock, Esther Hulleman, Nikita Popov, Rudi Beier, Sandra Bernard, Micaela Quarto, Maria Capra, Stephan Goettig, Ulrike Kogel, Martin Scheffner, Kristian Helin, Martin Eilers, The Ubiquitin Ligase HectH9 Regulates Transcriptional Activation by Myc and Is Essential for Tumor Cell Proliferation Cell. ,vol. 123, pp. 409- 421 ,(2005) , 10.1016/J.CELL.2005.08.016
Norio Yamamoto, Kenji Tanigaki, Masayuki Tsuji, Daisuke Yabe, Juichi Ito, Tasuku Honjo, Inhibition of Notch/RBP-J signaling induces hair cell formation in neonate mouse cochleas Journal of Molecular Medicine. ,vol. 84, pp. 37- 45 ,(2006) , 10.1007/S00109-005-0706-9