Modelling Binuclear Metallobiosites: Insights from Pyrazole‐Supported Biomimetic and Bioinspired Complexes

摘要: Numerous enzymes use two closely spaced metal ions to activate and transform small molecules. This allows these biocatalysts perform diverse physiological functions, achieving impressive chemistry under remarkably mild conditions. Model studies of metalloenzymes contribute furthering our understanding the unusual mechanistic aspects interplay cooperative effects used by Nature, help provide clues as how such reactivity might be harnessed for applications outside natural systems. microreview describes synthetic models binuclear metalloenzymes, focusing on complexes which are bridged pyrazole ligand scaffolds. Structural functional iron, nickel, copper zinc active sites discussed, in addition several cobalt possessing biologically relevant features. Metal separation secondary-coordination-sphere interactions recurring themes aid highlighting common importance native enzymes.