Treatment of reactive hypoglycemia with the macrobiotic Ma-pi 2 diet as assessed by continuous glucose monitoring: The MAHYP randomized crossover trial

摘要: Abstract Background and Aims Nutritional therapy is recommended for management of reactive hypoglycemia (RH), a condition characterized by that occurs within four hours after meal. The macrobiotic Ma-Pi 2 diet improves glycemic control in subjects with type diabetes. We explored the effect this on outcomes non-diabetic individuals RH. Materials Methods Twelve RH were randomized to three days crossover design. Subjects received snacks two out each three-day period only, monitored using continuous glucose monitoring. 24-h was divided into daytime (08:00–22:30 h [subdivided ‘daytime without snacks’ snacks’]) night-time (22:31–07:59 h). effects diets number events (blood  180 mg/dL (4.4 mmol/L) determined. Results There significantly fewer than during (− 2.5 events; 95% CI: -7.5, 0.0; P = 0.022) (− 4.25 -7.5; − 2.0; P = 0.013) but no difference at night. percentage readings interval 71–80 mg/dL (3.9–4.4 mmol/L) higher (P = 0.03 both), while 91–100 mg/dL (5.1–5.6 mmol/L) (P = 0.02). Conclusions reduced blood excursions day, thereby facilitating represents an effective nutritional tool