Synthesis of 2-aryl-3-(2-cyanoethyl)aziridines and their chemical and enzymatic hydrolysis towards γ-lactams and γ-lactones
作者： Karen Mollet , Lena Decuyper , Saskia Vander Meeren , Nicola Piens , Karel De Winter
DOI: 10.1039/C4OB02615B
关键词: Organic synthesis 、 Enzymatic hydrolysis 、 Nitrilase 、 Hydrolysis 、 Biocatalysis 、 Nitrile 、 Organic chemistry 、 Aryl 、 Chemistry 、 Alkylation
摘要: Trans- andcis-2-aryl-3-(2-cyanoethyl)aziridines were transformed into 4-[aryl(alkylamino)methyl]butyrolactones and/or 5-[aryl(hydroxy)methyl]pyrrolidin-2-onesviachemical and enzymatic hydrolysis of the cyano group, followed by ring expansion.
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