Negative-pressure ventilation: better oxygenation and less lung injury.
作者： Francesco Grasso , Doreen Engelberts , Emma Helm , Helena Frndova , Steven Jarvis
DOI: 10.1164/RCCM.200707-1004OC
关键词: Tidal volume 、 Ventilation perfusion mismatch 、 Ventilation/perfusion ratio 、 Mechanical ventilation 、 Normocapnia 、 Lung injury 、 Medicine 、 Breathing 、 Anesthesia 、 Respiratory minute volume
摘要: Rationale: Conventional positive-pressure ventilation delivers pressure to the airways; in contrast, negative is delivered globally chest and abdomen.Objectives: To test hypothesis that with results better oxygenation less injury than positive pressure.Methods: Anesthetized, surfactant-depleted rabbits were ventilated for 2.5 hours pairs (positive or negative). Tidal volume was 12 ml · kg−1, normocapnia maintained by adjusting respiratory rate, FiO2 1.0.Measurements Main Results: Lung assessed histologic scoring, perfusion using thermodilution (global perfusion), injected intravascular microspheres (regional perfusion); dynamic computed tomography used determine inflation patterns. Negative associated a higher PaO2, lower Pa–PetCO2 gradient (despite identical minute ventilation), lung injury. regional) similar negative...
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