Tri-heterocyclic derivatives, preparation process and uses thereof
作者： Yajun Yu , Heping Yang , Daxin Gao
DOI:
关键词: Chemistry 、 Organic chemistry 、 Heterocyclic derivatives
摘要: The present invention relates to a tri-heterocyclic derivatives, preparation process and uses thereof, specifically derivatives of the formula (I) or pharmaceutically acceptable salt process, further composition comprising compounds (I), their pharmaceutical use as inhibitors kinase.
lens.org 参考文章(6)
Qi Chao, Shripad Bhagwat, Kelly G. Sprankle, Robert M. Grotzfeld, Hitesh K Patel, Imidazolothiazole compounds for the treatment of disease ,(2007)
Joyce K. James, Darren E. Inski, Julius L. Apuy, Imidazolothiazole compounds as modulators of protein kinase ,(2009)
Timothy Bruno Lowinger, Uday Khire, Jeffrey Johnson, Jill E. Wood, Aniko Redman, William J. Scott, Roger A. Smith, Holger Paulsen, Bernd Riedl, Jacques Dumas, Wendy Lee, Holia Hatoum-Mokdad, Inhibition of p38 kinase activity using substituted heterocyclic ureas ,(1998)
Shripad S. Bhagwat, Isotopically enriched or fluorinated imidazo[2,1-b][1,3]benzothiazoles ,(2010)
Qi Chao, Kelly G. Sprankle, Robert M. Grotzfeld, Andiliy G. Lai, Todd A. Carter, Anne Marie Velasco, Ruwanthi N. Gunawardane, Merryl D. Cramer, Michael F. Gardner, Joyce James, Patrick P. Zarrinkar, Hitesh K. Patel, Shripad S. Bhagwat, Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor. Journal of Medicinal Chemistry. ,vol. 52, pp. 7808- 7816 ,(2009) , 10.1021/JM9007533
Alan Schwartz, Melanie J. Roe, Stephan D. Parent, Shripad S. Bhagwat, Valeriya N. Smolenskaya, Wei Lai, Solid forms comprising n-(5-tert-butyl-isoxazol-3-yl)-n'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, compositions thereof, and uses therewith ,(2008)